Current Topics in Microbiology and Immunology : Volume 102

Current Topics in Microbiology and Immunology : Volume 102

Description

Binding of various ligands (hormones, neurotransmitters, immunological stimuli) to membrane receptors induces the following changes: 1. Receptor redistribution (clustering, "capping") 2. Conformational changes that can be detected by fluorescent probes 3. Alteration in membrane fluidity (spin label and fluorescence polarization probes) 4. Changes in fluxes of ions and metabolites 5. Increased phospholipid turnover (especially of phosphatidyl inositol) 6. Activation of membrane-bound enzymes (adenyl cyclase, ATPase, transmethylases). Some of the early changes resulting from or associated with the binding (adsorption) of virions to the host cell membrane are of the same type. Adsorption of animal viruses to cells is the ftrst step in a chain of events resulting in the production of progeny virus on the one hand and in damage to cells and tissues on the other. In the classical studies of viral infection, cells are adsorbed with virus, usually for 60 min, and the changes induced by the virus in the host cell are recorded thereafter. In the past decade, more and more studies have been aimed at the events occurring in these ftrst 60 min of the so-called adsorption period. These studies deal with the nature of adsorption, e. g. , the ligand-receptor type of interaction between the virus and the cell membrane. Many receptors for viruses were identifted and so were the viral proteins which take part in adsorption.


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Details

Author(s)
M. Cooper, W. Henle, P. H. Hofschneider, H. Koprowski, F. Melchers, R. Rott, H. G. Schweiger, P. K. Vogt, Rolf M. Zinkernagel
Format
Paperback | 154 pages
Dimensions
170 x 244 x 8.64mm | 289g
Publication date
07 Dec 2011
Publisher
Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Imprint
Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Publication City/Country
Berlin, Germany
Language
English
Edition Statement
Softcover reprint of the original 1st ed. 1983
Illustrations note
IV, 154 p.
ISBN10
3642689086
ISBN13
9783642689086